Among patients who have had an ischemic stroke, use of cholesterol-lowering statin medications is not associated with subsequent intracerebral hemorrhage.

After stroke or transient ischemic attack, patients are at increased risk for recurrent events. Results from the Stroke Prevention by Aggressive Lowering of Cholesterol Levels ( SPARCL ) trial and the Heart Protection Study ( HPS ) were used to develop clinical practice guidelines which recommend therapy with statins to prevent further cerebrovascular problems. This treatment appears to be associated with a reduced risk of ischemic stroke in those patients. However, together these two trials suggest a sizable increase in hemorrhagic stroke related to statin therapy in patients with a history of stroke or transient ischemic attack.

Daniel G. Hackam, from the University of Western Ontario, London ( Canada ), and colleagues, conducted a retrospective study of six Canadian health care databases. They included 17,872 patients age 66 years and older who were admitted to Ontario hospitals for acute ischemic stroke from July 1994 to March 2008. Equal numbers of patients did not receive statins ( control group ) and did receive statins ( intervention group ).
Patients were followed from 120 days after hospital discharge until they developed intracerebral hemorrhage ( ICH ), died or reached the March 31, 2010 endpoint of the study; the median follow-up time was 4.2 years.

Researchers found 213 episodes of intracerebral hemorrhage; the rate was slightly lower in patients treated with statins ( 2.94 vs. 3.71 episodes per 1,000 patient-years, respectively ), but the difference was not statistically significant. Strokes were hemorrhagic in 10.09% of patients receiving statins and 10.23% of patients in the control group. Analysis of patient subgroups and statin dosage, and of screening tests that could indicate a healthy user bias or differences in quality of care, also did not demonstrate an association between medication use and intracerebral hemorrhage.

At present, more than 80% of patients discharged from the hospital with a diagnosis of ischemic stroke are prescribed statin therapy.
In a large North American jurisdiction, researchers found no evidence that such patients are at higher risk for cerebral bleeding than individuals who do not receive statins.

Source: Archives of Neurology, 2011

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