Intravenous Dexamethasone may reduce risk of dying from bacterial meningitis

New research has shown that an intravenous Dexamethasone treatment may cut a person’s risk of dying from bacterial meningitis. The research ...

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Alzheimer’s disease: Vitamin B12 may reduce risk

A new study has shown that Vitamin B12 may protect against Alzheimer’s disease, adding more evidence to the scientific debate ...

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Severe headache: Acetylsalicylic acid given intravenously is safe and effective

A new study has shown that Acetylsalicylic acid ( Aspirin ), given intravenously ( IV ), may be a safe ...

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Amyotrophic lateral sclerosis: Lithium shows no benefit

A new study has found that the drug Lithium is not effective in treating people with amyotrophic lateral sclerosis, also ...

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Provenge, cellular immunotherapy for advanced prostate carcinoma

The FDA ( Food and Drug Administration ) has approved Provenge ( Sipuleucel-T ), a new therapy for certain men ...

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FDA: increased risk of death with Tygacil compared to other antibiotics

The FDA ( Food and Drug Administration ) has informed healthcare professionals of an increased mortality risk associated with the ...

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EMA: the use of Modafinil should be restricted to the treatment of narcolepsy

The European Medicines Agency ( EMA ) has recommended restricting the use of Modafinil-containing medicines. Modafinil should only be used ...

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Chronic lymphocytic leukaemia: NICE recommends MabThera for NHS use

Rituximab ( MabThera ) is available to certain NHS patients with chronic lymphocytic leukaemia. The National Institute for Health and Clinical ...

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Moderate-to-severe Alzheimer's disease: higher dose Aricept 23 mg approved by FDA

Eisai and Pfizer have received approval from the FDA ( Food and Drug Administration ) for Aricept ( Donepezil ) ...

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Bevacizumab-based therapy extends survival beyond fourteen months in patients with advanced non-small cell lung cancer

New data have shown that Bevacizumab-based therapy provides a median overall survival of 14.6 months with a range of chemotherapies ...

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PLX4032: preliminary phase 2 data in metastatic melanoma

Preliminary data from a pivotal Phase 2 clinical trial of PLX4032 ( RG7204 ) in metastatic melanoma, have shown significant ...

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Chronic obstructive pulmonary disease: beta-blockers may be associated with benefits

Patients with chronic obstructive pulmonary disease ( COPD ) may have fewer respiratory flare-ups and longer survival if they take ...

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Raltegravir in patients whose HIV is controlled on Kaletra-based therapy

Two Phase III studies ( SWITCHMRK-1 and -2 ) evaluating the effect of switching patients whose HIV is controlled on ...

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Paroxysmal atrial fibrillation: prescription Omega-3 no better than placebo

Omega-3 fatty acids don’t prevent the recurrence of atrial fibrillation. P-OM3 trial ( Efficacy and Safety of Prescription Omega-3 Acid Ethyl ...

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ASCEND-HF trial: Nesiritide is safe, but shows no significant benefit on symptoms or mortality in acutely decompensated heart failure

In a large clinical trial, the drug Nesiritide ( Natrecor ) proved to be safe but had little effect on ...

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Higher dose of Clopidogrel no better than standard dose for high risk patients with drug-coated stents

Compared to the standard dose, a high dose of Clopidogrel ( Plavix ) does not reduce the incidence of death, ...

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Atrial fibrillation: Rivaroxaban comparable to Warfarin in preventing stroke and other complications

A new anti-clotting drug, Rivaroxaban ( Xarelto ) is as effective as the standard medication in preventing stroke and blood ...

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CETP inhibitors: safety and efficacy of Anacetrapib in patients with coronary heart disease

The DEFINE ( Determining the EFficacy and Tolerability of CETP INhibition with AnacEtrapib ) trial was an 18-month study in ...

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Two therapies slow progression of diabetic retinopathy

In high-risk adults with type 2 diabetes mellitus, two therapies may slow the progression of diabetic retinopathy. Intensive blood glucose ...

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Erythropoiesis-stimulating agents should be prescribed and used under a risk management program

The FDA ( Food and Drug Administration ) is requiring all drugs called Erythropoiesis-Stimulating Agents ( ESAs ) to be ...

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New indication for Afinitor: treatment of patients with subependymal giant cell astrocytoma associated with tuberous sclerosis

The FDA ( Food and Drug Administration ) approved Afinitor ( Everolimus ) to treat patients with subependymal giant cell ...

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Eltrombopag reduces bleeding, and increases platelet levels in idiopathic thrombocytopenic purpura

New data from two long-term studies ( RAISE: 197 patients and EXTEND: 144 patients ) have shown that patients with ...

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NICE does not recommend Ofatumumab as a treatment for refractory chronic lymphocytic leukaemia

The NICE ( National Institute for Health and Clinical Excellence ) has published three separate pieces of guidance for the ...

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Prolia as a treatment option for certain postmenopausal women who are at increased risk of primary and secondary osteoporotic fractures if other treatments are unsuitable

NICE ( National Institute for Health and Clinical Excellence ) recommends a range of treatment options for reducing the risk ...

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Revolade for the treatment of idiopathic thrombocytopenic purpura is not recommended

In final guidance published by NICE ( National Institute for Health and Clinical Excellence ) Eltrombopag ( Revolade ) is ...

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Increased risk of suicide with Vigabatrin, Levetiracetam and Topiramate

While the FDA ( Food and Drug Administration ) is requiring a warning of an increased risk of suicide for ...

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Votrient in the treatment of advanced renal cell carcinoma and ovarian carcinoma

GlaxoSmithKline ( GSK ) has announced results from ongoing Phase II studies of Pazopanib ( Votrient ) in advanced or ...

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Diabetes mellitus type 2: restrict the use of Rosiglitazone

The FDA ( Food and Drug Administration ) announced that it will significantly restrict the use of the diabetes drug ...

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Erbitux does not add benefit to the NORDIC FLOX regimen in treatment of metastatic colorectal cancer

Adding the targeted drug Cetuximab ( Erbitux ) to a three-drug chemotherapy regimen for first-line treatment of metastatic colorectal cancer ...

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PARP inhibitors: Iniparib improves overall survival in metastatic triple-negative breast carcinoma

Women with an aggressive subtype of metastatic breast cancer appear to live an average of almost five months longer when ...

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Advanced neuroendocrine tumors: Afinitor delays tumor progression

The results of a large Phase-III clinical trial have shown that the drug Everolimus ( Afinitor ) delays tumor progression ...

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Vectibix fails to add overall survival benefit in recurrent, metastatic head and neck squamous cell carcinoma

Adding the monoclonal anti-EGFR antibody Panitumumab ( Vectibix ) to chemotherapy did not significantly improve overall survival for patients with ...

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Votrient shows promise in relapsed, refractory urothelial carcinoma

An ongoing Phase-II trial investigating Pazopanib ( Votrient ) for metastatic urothelial cancer has generated promising early results. Urothelial cancers affect ...

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Zytiga improves survival in metastatic castration-resistant prostate carcinoma

Patients with metastatic castration-resistant prostate cancer who have progressed after chemotherapy live significantly longer if treated with the drug Abiraterone ...

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Avastin added to chemotherapy reduces the risk of disease progression during the first year of treatment in patients with newly diagnosed ovarian carcinoma

Adding Bevacizumab ( Avastin ) to chemotherapy as a treatment for newly diagnosed ovarian cancer reduces the risk of disease ...

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Lung adenocarcinoma progressed after treatment with EGFR inhibitors: Afatinib improves progression-free

Lung cancer patients who have already been treated with the EGFR inhibitors Erlotinib or Gefitinib seem to gain further benefits ...

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Erbitux added to chemotherapy doubles response rate in triple negative breast carcinoma

Targeting the epidermal growth factor receptor can provide substantial clinical benefit for women with hard-to-treat triple-negative breast cancer. A Phase-II randomized ...

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Ovarian carcinoma resistant or refractory to Platinum-based chemotherapy: promising results with MLN8237

Researchers at Dana-Farber Cancer Institute in the USA reported the results of the single-agent trial of the drug, called MLN8237, ...

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Tarceva plus MetMAb in advanced non-small cell lung carcinoma

A subset of lung cancer patients seem to live longer and experience delays in disease progression when a new drug ...

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Advanced non-small cell lung cancer with EGFR activating mutations: Iressa does not improve overall survival

Data from the IPASS study showed that overall survival ( OS ) was similar, with no significant difference, between Gefitinib ...

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Glucosamine, Chondroitin do not reduce joint pain or have an impact on narrowing of joint space in osteoarthritis of the hip or knee

Two supplements taken by millions of people around the world to combat joint pain do not work, finds research published ...

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Potential increased risk of bladder carcinoma after two years exposure to Pioglitazone, an antidiabetic drug

L’FDA ( Food and Drug Administration ) is reviewing data from an ongoing, ten-year epidemiological study designed to evaluate whether ...

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Increased mortality risk associated with drugs for insomnia or anxiety

Taking medications to treat insomnia and anxiety increases mortality risk by 36%, according to a study conducted by Belleville, at ...

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Patients with acute coronary syndrome and on Fondaparinux: safety of two intravenous Heparin doses as adjunct to PCI

Results from the FUTURA/OASIS 8 study provide initial evidence that a low dose of unfractionated Heparin does not reduce the ...

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Switch to metronomic chemotherapy could offer new treatment option in metastatic renal-cell cancer

A new multi-targeted chemo-switch drug regimen shows promising anti-tumour activity with manageable side effects in patients with metastatic renal-cell carcinoma ...

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Xarelto is an effective and safe treatment for acute symptomatic deep vein thrombosis

Results of the Phase III EINSTEIN-DVT study have shown that the oral anticoagulant Rivaroxaban ( Xarelto ) achieved the primary ...

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Patients with paroxysmal atrial fibrillation and without structural heart disease: sartans do not reduce the number of atrial fibrillation episodes

Atrial fibrillation ( AF ) is a progressive chronic disease in which episodes become more frequent and long-lasting over time. ...

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Atrial fibrillation: Apixaban reduces risk of stroke and systemic embolism

The phase 3 AVERROES ( Apixaban Versus Acetylsalicylic acid to Prevent Strokes ) trial, designed to show the superiority of ...

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Nexavar can reduce the size of tumor prior to surgery in advanced kidney carcinoma

Physicians who conducted a pilot study at University of North Carolina ( UNC ) Lineberger Comprehensive Cancer Center found that ...

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A vaccine made with leukemia cells in patients with chronic myeloid leukaemia treated with Gleevec

Preliminary studies by Researchers at Johns Hopkins Kimmel Cancer Center, have shown that a vaccine made with leukemia cells may ...

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Mirena LNG-IUS appears to prevent the development of benign endometrial polyps in breast carcinoma patients taking Tamoxifen

Adjuvant Tamoxifen ( Nolvadex ) reduces the risk of breast cancer recurrence in women with estrogen receptor-positive breast carcinoma. Tamoxifen ...

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Abatacept for rheumatoid arthritis: moderate-level evidence regarding efficacy and safety

Abatacept ( Orencia ) inhibits the co-stimulation of T cells and disrupts the inflammatory chain of events that leads to ...

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Vitamin-D supplementation for cystic fibrosis: no evidence of benefit or harm

Cystic fibrosis is a genetic disorder with multiorgan effects. In a subgroup with pancreatic insufficiency malabsorption of the fat soluble ...

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SAMe for osteoarthritis of the knee or hip: routine use should not be advised

Osteoarthritis is the most common form of joint disease and the leading cause of pain and disability in the elderly. ...

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Europe: Vpriv approved for type 1 Gaucher disease

European Commission has granted marketing authorisation for Vpriv ( Velaglucerase alfa ), a human cell line derived enzyme replacement therapy ...

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Drug-resistant chronic myeloid leukemia: Tasigna and Sprycel improve responses over Gleevec

Two drugs approved for treatment of drug-resistant chronic myeloid leukemia ( CML ) provide patients with quicker, better responses as ...

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Ketamine quickly reduces symptoms of depression in treatment-resistant bipolar disorder

A single intravenous dose of the anesthetic agent Ketamine appears to reduce symptoms of depression within 40 minutes among those ...

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Management of renal cell cancer

Renal cell carcinoma ( RCC ) accounts for about 3% of all solid tumours in adults, and worldwide, more than ...

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A comparison between Stelara and Enbrel in management of moderate to severe psoriasis

Researchers at The University of Manchester ( UK ) have compared the drugs Etanercept ( Enbrel ) and Ustekinumab ...

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TNF-alpha blockers linked to reports of malignancies in children

The FDA ( Food and Drug Administration ) has received reports of malignancies in children using tumor necrosis factor alpha ...

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Avodart in the prevention of prostate cancer

An editorial about REDUCE ( Reduction by Dutasteride of Prostate Cancer Events ) trial by Fritz H Schröder and Monique ...

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Avodart reduces risk of prostate cancer diagnosis in high-risk men

Dutasteride ( Avodart ) has shown to reduce the risk of a prostate cancer diagnosis by 23 percent in men ...

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Doxycycline should not be recommended for the treatment of osteoarthritis of the knee or hip

Osteoarthritis is a chronic joint disease that involves degeneration of articular cartilage. Pre-clinical data suggest that Doxycycline might act as ...

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Acute postoperative pain in adults: single dose oral Ketoprofen and Dexketoprofen

Ketoprofen is a non-selective non-steroidal anti-inflammatory drug ( NSAID ) used to treat acute and chronic painful conditions. Dexketoprofen is ...

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Chronic neuropathic pain in adults: topical Capsaicin

Topical creams with Capsaicin are used to treat pain from a wide range of chronic conditions including neuropathic pain. Following ...

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Diabetic macular oedema: antiangiogenic therapy with Bevacizumab

Diabetic macular oedema is a common complication of diabetic retinopathy. The retina at the macula thickens and this can cause ...

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Formoterol versus Salmeterol for chronic asthma: serious adverse events

An increase in serious adverse events with both regular Formoterol and regular Salmeterol in chronic asthma has been demonstrated in ...

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Sartans: Benicar increases risk of death

The FDA ( Food and Drug Administration ) has not concluded that Olmesartan ( Benicar ) increases the risk of ...

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Myocardial infarction: Brilique more effective than Plavix

New research has shown that the stronger anticlotting medication Ticagrelor ( Brilinta; Brilique in Europe ) reduces death rates without ...

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Increased risk of lung cancer linked to sartans

Sartans, or Angiotensin-receptor blockers, are a class of blood-pressure-lowering drug that is also used for the treatment of heart failure ...

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Antiepileptic drugs: increased risk of suicide with Keppra, Sabril and Topamax

A new study has shown that only certain epilepsy drugs may increase the risk of suicide. The study is published ...

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Treatment of behavioral symptoms in older patients with dementia with atypical antipsychotics linked to increased risk of death

The use of atypical antipsychotics to treat elderly patients with dementia appears to have decreased following a 2005 FDA ( ...

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Favorable risk-benefit ratio for modified-release oral opioids of the WHO level III scale for the management of pain

The EMA ( European Medicines Agency ) has finalised a review of modified-release oral opioids of the WHO level III ...

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Increased risk of suicide associated with some anticonvulsant medications

Data of an analysis of prescription and clinical claims suggests that the use of certain anticonvulsant medications may be associated ...

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Asthma: FDA's recommendations on the appropriate use of LABAs

Long-acting beta-agonists ( LABAs ), a class of medications used for the treatment of asthma and chronic obstructive pulmonary disease ...

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Pediatric patients: use of antipsychotics associated with significant weight gain

Many pediatric and adolescent patients who received second-generation antipsychotic medications experienced significant weight gain, along with varied adverse effects on ...

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Tibolone increases risk of recurrence in breast tumor survivors

Tibolone ( Livial ), a synthetic steroid used to treat menopausal symptoms and to prevent osteoporosis, significantly increases the risk ...

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EMA: Rotarix continues to have a positive benefit-risk balance

Following a review of the oral vaccine Rotarix, the European Medicines Agency’s Committee for Medicinal Products for Human Use ( ...

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European Medicines Agency is reviewing risk-benefit ratio of Avandia, Avandamet and Avaglim

The EMA ( European Medicines Agency ) is currently reviewing Rosiglitazone to determine the impact of new data from recent ...

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EMA: restricting the use of Modafinil-containing medicines

The EMA ( European Medicines Agency ) has recommended restricting the use of Modafinil-containing medicines. The medicine should only be ...

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EMA: favorable risk-benefit ratio for topical formulations of Ketoprofen

Following a review of topical formulations of Ketoprofen, the European Medicines Agency’s Committee for Medicinal Products for Human Use ( ...

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Possible development of prostate cancer with Stalevo, a Parkinson's disease medication

The FDA ( Food and Drug Administration ) is evaluating clinical trial data that may suggest that patients taking Stalevo, ...

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Risk of cancer associated with angiotensin-receptor blockers

Angiotensin-receptor blockers ( also known as sartans ) are a widely used drug class approved for treatment of hypertension, heart ...

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Increased risk of muscle injury with high-dose Zocor

Based on review of data from a large clinical trial and data from other sources, the FDA ( Food and ...

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Angiotensin receptor blockers: Benicar associated with cardiovascular events

The FDA ( Food and Drug Administration ) is evaluating data from two clinical trials in which patients with type ...

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Sartans linked to cancer: FDA is conducting a safety review

The FDA ( Food and Drug Administration ) is conducting a review of the class of medications known as angiotensin ...

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Obesity and overweight: Sibutramine is contraindicated in patients with history of cardiovascular disease or uncontrolled hypertension

The FDA ( Food and Drug Administration ) has reviewed additional data that indicate an increased risk of myocardial infarction ...

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Invirase in combination with Norvir linked to abnormal heart rhythm in patients with HIV infection ( 2010 )

The FDA ( Food and Drug Administration ) is reviewing clinical trial data about a potentially serious effect on the ...

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FDA has approved the use of oral Zyprexa in adolescent patients

The FDA ( Food and Drug Administration ) has approved the use of oral Zyprexa ( Olanzapine ) in adolescents ...

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GnRH agonists linked to increased risk of diabetes and cardiovascular diseases in men

GnRH ( Gonadotropin-Releasing Hormone ) agonists, a class of drugs primarily used to treat men with prostate cancer, have been ...

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Postmenopausal breast cancer: role of bisphosphonates

Bisphosphonates are routinely given to women with postmenopausal breast cancer, but new data suggests that these agents may play a ...

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Head and neck tumor: Cetuximab increases survival for up to 5 years

Adding Cetuximab ( Erbitux ) to radiation therapy prolongs survival in patients with locally advanced head and neck cancer compared ...

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Acetylsalicylic acid use after colorectal tumor diagnosis associated with improved survival

Men and women with colorectal cancer and began regular use of Acetylsalicylic acid ( Aspirin ) had a lower risk ...

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Renal cell carcinoma: interventional cryoablation is effective

Freezing kidney tumors should be the gold standard or first treatment option for all individuals with tumors that are 4 ...

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Advanced non-small cell lung cancer: Vandetanib has shown clinical benefit when combined with Docetaxel

When combined with standard chemotherapy, Vandetanib ( Zactima ) improves progression-free survival for patients with advanced non-small cell lung cancer. The ...

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Mylotarg has been voluntarily withdrawn from Pfizer

Pfizer has announced the voluntary withdrawal from the US market of the drug Mylotarg ( Gemtuzumab ozogamicin ) for patients ...

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Hedgehog inhibitor yields positive response in people with advanced basal cell skin cancer and with medulloblastoma

The Hedgehog signaling pathway is involved in a preliminary study and case report describing positive responses to an experimental anticancer ...

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Myocardial infarction: patients treated with more antithrombotics have increased risk of hospital admission for bleeding

In patients with myocardial infarction, risk of hospital admission for bleeding increases with the number of antithrombotic drugs used. Patients ...

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Invasive procedures: Brilique is a better option than Plavix in patients with acute coronary syndromes

A new research has shown that Ticagrelor ( Brilinta; Brilique in Europe ) reduces death rates without increasing bleeding compared ...

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Methylprednisolone added to Interferon beta-1a reduces relapse rate in patients with relapsing-remitting multiple sclerosis

Addition of oral Methylprednisolone to standard treatment of subcutaneous Interferon beta-1a substantially reduces the relapse rate in patients with relapsing-remitting ...

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