High-sensitivity C-reactive protein screening only minimally improved risk assessment in middle-aged patients with traditional cardiovascular disease risk factors.

Researchers analyzed 4,853 patients in the United Kingdom and Ireland who were part of the Anglo-Scandinavian Cardiac Outcomes Trial ( ASCOT ), which compared the cholesterol-lowering effects of the drug Atorvastatin to placebo.

They found that participants’ baseline levels of low-density lipoprotein ( LD L) cholesterol and levels of C-reactive protein ( CRP ) were both predictive of cardiovascular events. However, after the researchers considered other risk factors at the start of the study, or in-trial changes in LDL, the changes in CRP were no longer linked to cardiovascular events.

Participants in the analysis were 65 years old on average, predominantly male, with total cholesterol levels under 250 milligrams per deciliter ( mg/dL ) of blood, including levels considered normal to moderately elevated. In the treatment group, the statin drug reduced LDL by 40 percent and reduced median CRP by 27 percent over six months.

During 5.5 years of follow-up, 485 cardiovascular events occurred in ASCOT participants. Those cases were age and sex-matched with 1,367 controls from within the group who hadn’t had a cardiovascular event. The researchers then used statistical models to evaluate the association between cardiovascular events and patients’ cholesterol and CRP levels.

In those taking Atorvastatin, LDL below the median while on treatment was associated with a reduction in cardiovascular events compared with those taking placebo or with those with LDL above the median. This risk reduction was unchanged after the researchers adjusted for the participants’ other baseline risk factors. However, in those taking Atorvastatin, CRP below the median was not associated with reduced cardiovascular events compared with those with CRP above the median after adjusting for other risk factors and the changes in LDL.

The lack of added value of CRP measurement in the patients was surprising in light of recent studies such as the randomized, placebo-controlled JUPITER trial.

In JUPITER, researchers found that taking a cholesterol-lowering statin reduced first cardiovascular events by 37 percent in people who primarily had normal cholesterol levels and no other risk factors except elevated CRP.

ASCOT doesn’t support the hypothesis that CRP improves cardiovascular risk prediction or that the CRP-lowering effect of statins reduces cardiovascular events.

Source: American Heart Association’s Scientific Sessions, 2010

XagenaMedicine2010


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